HOLYOKE, Mass. (WWLP) – Multiple people are in the hospital, and an infant is dead after a shooting in downtown Holyoke Wednesday afternoon.

According to Hampden District Attorney’s Office Spokesperson Jim Leydon, just before 1 p.m., members of the Holyoke Police Department were called to a reported shooting in the 100 block of Sargeant Street. Leydon added that three men were involved in an altercation, during which a shooting occurred, and one of the rounds from that altercation struck a public transportation bus and an uninvolved female occupant, who was seated in the bus.

A woman on the bus, who was pregnant, was treated at a nearby hospital and reported to be in critical condition. The infant, who was delivered, and needed life-saving medical services, tragically passed away, according to officials.

“There are no words that could be sufficient in the face of what happened today to people in the Holyoke community, including innocent bystanders on a regional transit authority bus.  Our thoughts are with them. And so are our hearts and our sorrow. Our prayers go out to everyone who has been, and will continue to be, affected by this senseless act of violence.”

Statement from Acting Transportation Secretary and CEO Monica Tibbits-Nutt

All suspects involved are in custody, and receiving treatment at nearby hospitals. This incident is being investigated by the Massachusetts State Police Detective Unit along with the Hampden County District Attorney’s Office, and Holyoke Police.

“I want to extend my deepest and sincerest condolences to the family.

I want the public to know that I am equally outraged and frustrated with these senseless acts of violence and illegal activity on our streets. I struggle with it every day attempting to offer a balanced solution. Quite frankly, I have lost my patience. I plan to work with all resources available to me to push this nonsense out of our city.

Thank you everybody for your patience during this very difficult time in our city.”

Mayor Joshua A. Garcia

PHOTOS: Holyoke shooting

MAP: Traffic near Sargeant and Maple Streets in Holyoke

This incident happened just hours after the Holyoke Police held a news conference to discuss the amount of gunfire that has been picked up by the ShotSpotter system installed in the city in March. The ShotSpotter program is a detection system that allows police to detect, find, and respond to gunfire.

VIDEO: Footage sent to 22News from a bystander

Holyoke ShotSpotter Report

According to the Holyoke Police Department, in the past 6 months, their ShotSpotter system has detected 113 incidents involving gunfire, 72 of which happened near a playground and 27 near a school, and 110 incidents were reported near a business.

Holyoke police recovered 457 rounds, seven guns, and made 10 arrests. They also identified six victims. Police say that many of these ShotSpotter activations do not generate a 911 call from people in the area.

22News is covering this story and will update as soon as additional information is released.