What is the difference between the COVID-19 vaccines?

There are two COVID-19 vaccines that have been approved so far in the U.S., and there could soon be more coming.

What is the difference between the COVID-19 vaccines?

Two men arrested for breaking and entering a home …

The Big E wraps up record breaking second weekend

Big Brothers/Big Sisters of Hampshire County hosts …

Rosh Hashanah, celebrating the Jewish New Year starts …

Heavy police presence seen on Stonina Drive in Chicopee

Halloween arrives at Six Flags New England with Fright …

New England Patriots home opener game starts on Sunday

Florence man arrested for driving on sidewalk towards …

Will Bike 4 Food raising funds for the Food Bank …

Hundreds participate in Walk to End Alzheimer’s in …

Internal report finds three Stoughton Police officers …

Statewide Cannabis Cup Competition taking place

Latest

Two men arrested for breaking and entering a home …

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The Big E wraps up record breaking second weekend

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Big Brothers/Big Sisters of Hampshire County hosts …

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Rosh Hashanah, celebrating the Jewish New Year starts …

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Heavy police presence seen on Stonina Drive in Chicopee

Video /

Halloween arrives at Six Flags New England with Fright …

Video /

New England Patriots home opener game starts on Sunday

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Florence man arrested for driving on sidewalk towards …

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Will Bike 4 Food raising funds for the Food Bank …

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Hundreds participate in Walk to End Alzheimer’s in …

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Internal report finds three Stoughton Police officers …

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Statewide Cannabis Cup Competition taking place

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Breaking News

East Longmeadow man killed in wrong-way crash

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Wrong-way crash closes parts of I-91 North in Windsor

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Bicyclist seriously injured in Pittsfield car accident

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Two suspects indicted in connection with murder of …

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Palmer Police investigating unattended death on Orchard …

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Missing teens found safe following police search …

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NJ man sentenced to prison for scamming Westfield …

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Pedestrian dead after Granby Road accident in Chicopee

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Fire started in closet on Niagara St in Springfield

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Westfield woman arrested for Boston Children’s Hospital …

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Northampton, Amherst may receive migrants after alleged …

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Armed bank robbery suspect in Springfield arrested

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Local News

Two men arrested for breaking and entering a home …

Video /

The Big E wraps up record breaking second weekend

Video /

Big Brothers/Big Sisters of Hampshire County hosts …

Video /

Rosh Hashanah, celebrating the Jewish New Year starts …

Video /

Heavy police presence seen on Stonina Drive in Chicopee

Video /

Halloween arrives at Six Flags New England with Fright …

Video /

New England Patriots home opener game starts on Sunday

Video /

Florence man arrested for driving on sidewalk towards …

Video /

Miguel Estrella demand change

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Will Bike 4 Food raising funds for the Food Bank …

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Hundreds participate in Walk to End Alzheimer’s in …

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Rocket video Saturday evening

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22News I-Team

Springfield seeing an increase in panhandling on …

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I-Team: Former Westfield principal resigns from new …

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I-Team: Massachusetts lawmakers get firsthand look …

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Weather News

When is peak fall foliage in New England?

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Salvation Army sending disaster relief experts to …

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Autumnal Equinox: Equal day and night, beginning …

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Mexican earthquake causes ‘desert tsunami’ in Death …

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Gándara Center creates relief fund for Puerto Rico

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Early Afternoon Video Forecast

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How to help Puerto Ricans recovering from Hurricane …

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Tracking the Tropics: Where will Invest 98L go after …

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Temperatures will feel like fall weather on Friday

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Lawmakers demand action from government as Puerto …

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Springfield discusses steps to help Puerto Rican …

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Mass Appeal

Mass Appeal Premier Exterior and Design – the right …

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Mass Appeal: Art street festival to celebrate community …

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Lifestyle contributor Limor Suss shares her fall …

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Mass Appeal Climate change: It’s real, It’s us, It’s …

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Mass Appeal Community Corner with PeoplesBank: The …

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Mass Appeal An evening of inspiration and conversation …

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Mass Appeal Skip’s Outdoor Accents offers deals to …

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Mass Appeal This is the proper way to do a pushup

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Mass Appeal Vermont Flannel at the Big E

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Mass Appeal Science experiment to teach kids why …

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Mass Appeal Celebrating Hispanic Heritage month with …

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Mass Appeal MOSSO’s Mix and Match: A Chamber Music …

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Digital First

Florence man arrested for driving on sidewalk towards …

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Florence Night Out Festival on Saturday

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6 Brick’s, LLC opens to the public Saturday

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Nuestras Raíces hosts Harvest Festival in Holyoke …

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Nuestras Raíces hosts Harvest Festival in Holyoke …

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Fresh Paint Springfield hosts two mural unveilings

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Pittsfield police looking for 16-year-old

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Electric vehicle sales soar

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High Street Paving Holyoke

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FEMA: Smith College to get $4.4M reimbursement for …

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70+ Eversource employees clean riverbanks along Connecticut …

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Crime News

Two men arrested for breaking and entering a home …

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Heavy police presence seen on Stonina Drive in Chicopee

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Florence man arrested for driving on sidewalk towards …

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Internal report finds three Stoughton Police officers …

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On ‘Dateline’: Rape and murder of a 22-year-old in …

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25 pounds of marijuana seized from Chicopee home

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Michael Lyncosky of West Springfield held without …

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Easthampton workshop informs seniors about scams …

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Pittsfield brothers face life in prison after found …

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Suspect wanted for allegedly stealing in Chicopee

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Physical therapist in Northampton guilty of sexually …

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Boston Statehouse

Regulators hear mixed views on sports betting rollout

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Massachusetts COVID-19 Weekly Report: 45 new deaths, …

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State urged to create home heating oil reserve before …

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